PUBLISHED PAPERS

2018

 

Characterization of immune cell, endothelial, and renal responses upon experimental human endotoxemia.

Authors: Eveline P. van Poelgeest, Marlous R. Dillingh, Marieke de Kam, Karen E. Malone, Marleen Kemper, Erik S.G. Stroes, Jacobus Burggraaf, Matthijs Moerland

The BCR-ABL1 Inhibitors Imatinib and Ponatinib Decrease Plasma Cholesterol and Atherosclerosis, and Nilotinib and Ponatinib Activate Coagulation in a Translational Mouse Model

Authors: Marianne G. Pouwer, Elsbet J. Pieterman, Lars Verschuren, Martien P. M. Caspers, Cornelis Kluft, Ricardo A. Garcia, Jurjan Aman, J. Wouter Jukema, and Hans M. G. Princen

Adult aggressive behavior in humans and biomarkers: a focus on lipids and methylation

Authors: Fiona A. Hagenbeek, Jenny van Dongen, Cornelis Kluft, Thomas Hankemeier, Lannie Ligthart, Gonneke Willemsen, Eco J.C. de Geus, Jacqueline M. Vink, Meike Bartels, Dorret I. Boomsma

A Dose-Escalating Study With the Fetal Estrogen Estetrol in Healthy Men

Authors:Coelingh Bennink HJT, Zimmerman Y, Verhoeven C, Dutman AE, Mensinga T, Kluft C, Reisman Y, Debruyne FMJ

Genome-wide analysis of DNA methylation in buccal cells: a study of monozygotic twins and mQTLs.

Authors: van Dongen J, Ehli EA, Jansen R, van Beijsterveldt CEM, Willemsen G, Hottenga JJ, Kallsen NA, Peyton SA, Breeze CE5, Kluft C, Heijmans BT, Bartels M, Davies GE, Boomsma DI

2017

Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model.

Authors: van Koppen A, Verschuren L, van den Hoek AM, Verheij J, Morrison MC, Li K, Nagabukuro H, Costessi A, Caspers MPM, van den Broek TJ, Sagartz J, Kluft C, Beysen C, Emson C, van Gool AJ, Goldschmeding R, Stoop R, Bobeldijk-Pastorova I, Turner SM, Hanauer G, Hanemaaijer R.

2SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio.

Lin BD, Carnero-Montoro E, Bell JT, Boomsma DI, de Geus EJ, Jansen R, Kluft C, Mangino M, Penninx B, Spector TD, Willemsen G, Hottenga JJ

Assessing Safety of Thrombolytic Therapy.

Authors: Kluft C, Sidelmann JJ, Gram JB

2016

Clinical Evaluation of Humira® Biosimilar ONS-3010 in Healthy Volunteers: Focus on Pharmacokinetics and Pharmacodynamics

Authors: Dillingh MR, Reijers JA, Malone KE, Burggraaf J, Bahrt K, Yamashita L, Rehrig C, Moerland M

Vitreous and subretinal fluid concentrations of orally administered dabigatran in patients with rheumatogenous retinal detachment.

Authors: Mulder V.C, Kluft C, van Meurs J.C.

Comparison of three isolation techniques for human peripheral blood mononuclear cells: cell recovery and viability, population composition and cell functionality.

Authors: Grievink H.W, Luisman T, Kluft C, Moerland M, Malone K. E

Assessing Safety of Thrombolytic Therapy

Authors: Kluft C, Sidelmann J.J, Gram J.B.

Biological Variation of Hemostasis Variables in Thrombosis and Bleeding: Consequences for Performance Specifications

Authors: Moniek P.M. de Maat, Marianne van Schie, Cornelis Kluft, Frank W.G. Leebeek, and Piet Meijer

Causes of variation in the neutrophil-lymphocyte and platelet-lymphocyte ratios: a twin-family study.

Authors: Lin BD, Hottenga JJ, Abdellaoui A, Dolan CV, de Geus EJ, Kluft C, Boomsma DI, Willemsen G

Discovery of biochemical biomarkers for aggression: A role for metabolomics in psychiatry.

Authors: Hagenbeek FA, Kluft C, Hankemeier T, Bartels M, Draisma HH, Middeldorp CM, Berger R, Noto A, Lussu M, Pool R, Fanos V, Boomsma DI

2015

Effect of genome and environment on metabolic and and inflammatory profiles

Authors: Sirota M, Willemsen G, Sundar P, Pitts S.J, Polturi S, Prifti E, Kennedy S, Erhlich S.D, Neuteboom J, Kluft C, Malone K.E, Cox D.R, de Geus E.J, Boomsma D.I.

Longitudinal weight differences, gene expression, and blood biomarkers in BMI discordant identical twins

Authors: van Dongen J, Willemsen G, Heijmans B.T, Neuteboom J, Kluft C, Jansen R, Penninx B.W, Slagboom P.E, de Geus E.J, Boomsma D.I.

2014

Characterization of inflammation and immune cell modulation induced by low-dose LPS administration to healthy volunteers

Authors: Dillingh M.R, van Poelgeest E.P, Malone K.E, Kemper E.M, Stroes E.S.G, Moerland M, Burggraaf J

Plasma cotinine levels in cigarette smokers: impact of mental health and other correlates.

Authors: Bot M, Vink J, Milaneschi Y, Smit J.H, Kluft C, Neuteboom J, Penninx B

Applying caspase-1 inhibitors for inflammasome assays in human whole blood.

Authors: Lipinska K, Malone K. E, Moerland M, Kluft C

The contribution of the functional IL6R polymorphism rs2228145, eQTLs and other genome-wide SNPs to the heritability of plasma sIL-6R levels.

Authors: van Dongen J, Jansen R, Smit D, Hottenga J.J, Mbarek H, Willemsen G, Kluft C, Penninx B.W.J, Ferreira M.A, Boomsma D.I. de Geus E.J.C

Effects of sugammadex on activated partial thromboplastin time and prothrombin time in healthy subjects.

Authors: de Kam P.J, Grobara P, Prohn M, Höppener F, Kluft C, Bruggraaf J, Langdon R.B, Peeters P

The association of alcohol intake with γ-glutamyl transferase (GGT) levels: evidence for correlated genetic effects.

Authors: van Beek J.H.D.A, de Moor M.H.M, Geels L.M, Sinke M.R.T, de Geus E.J.C, Lubke G.H, Kluft C, Neuteboom J, Vink J.M, Willemsen G, Boomsma D.I

Consequences for the APTT due to direct action of factor XIa on factor X, resulting in bypassing factors VIII-IX

Authors: Kluft C, van Leuven C.J.M

 

2013

Exposure to secondhand smoke and depression and anxiety: a report from two studies in the Netherlands.

Authors: Bot M, Vink J.M, Willemsen G, Smit J.H, Neuteboom J, Kluft C, Boomsma D.I, Penninx B.W.J.H

Genetic architecture of the pro-inflammatory state in an extended twin-family design.

Authors: Neijts M, van Dongen J, Kluft C, Boomsma D.I, Willemsen G, de Geus E.J.C

Preincubation in the Prothrombinase-induced Clotting Time test (PiCT) is necessary for in vitro evaluation of fondaparinux and to be avoided for the reversible, direct factor Xa inhibitor, rivaroxaban.

Authors: Kluft C, Meijer P, Kret R, Burggraaf J

Diagnostic possibilities of specific fibrin(ogen) degradation products in relation to venous thromboembolism.

Authors: Haas F.J.L.M, Schutgens R.E.G, Biesma D.H, Laterveer R.H, Kluft C

The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection.

Authors: Willemsen G, Vink J.M, Abdellaoui A, den Braber A, van Beek J.H.D.A, Draisma H.H.M, van Dongen J, van’T Ent D, Geels L.M, van Lien R, Ligthart L, Kattenberg M, Mbarek H, de Moor M.H.M, Neijts M, Pool R, Stroo N, Kluft C, Suchiman H.E.D, Slagboom P.E, de Geus E.J.C, Boomsma D.I

Sex hormone-binding globulin as a marker for the thrombotic risk of hormonal contraceptives: a rebuttal.

Authors: Kluft C, Skouby S.O, Jespersen J, Burggraaf J

2012

Increased impact of a contraceptive vaginal ring with ethinyl estradiol and nestorone on C-reactive protein.

Authors: Rad M, Burggraaf J, Sitruk-Ware R.L, de Kam M.L, Cohen A.F, Kluft C

Preincubation in the Prothrombinase-induced Clotting Time test (PiCT) is necessary for in vitro evaluation of fondaparinux and to be avoided for the reversible, direct factor Xa inhibitor, rivaroxaban.

Authors: Kluft C, Meijer P, Kret R, Burggraaf J.

Biological variation in tPA-induced plasma clot lysis time.

Authors: Talens S, Malfliet J.J.M.C, Rudez G, Spronk H.M.H, Janssen N.A.H, Meijer P, Kluft C, de Maat M.P.M, Rijken D.C.

Discriminant analysis of the metabolic effects of a new combined contraceptive vaginal ring containing Nestorone/EE vs. a second-generation oral contraceptive containing levonorgestrel/EE.

Authors: Rad M, Burggraaf J, de Kam M.L, Cohen A.F, Kluft C

Association of depressive disorders, depression characteristics and antidepressant medication with inflammation.

Authors: Vogelzangs N, Duivis H.E, Beekman A.T.F, Kluft C, Neuteboom J, Hoogendijk W,  Smit J.H, de Jonge P, Penninx B.W.J.H

2011

Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo.

Authors: Sidelmann J.J, Skouby S.O, Kluft C, Winkler U, Vitzthum F, Schwarz H, Gram J, Jespersen J

Discriminant analysis of the metabolic effects of a new combined contraceptive vaginal ring containing Nestorone/EE vs. a secondgeneration oral contraceptive containing levonorgestrel/EE

Authors: Rad M, Burggraaf J, de Kam ML, Cohen AF, Kluft C.

Introduction to haemostasis from a pharmacodynamic perspective.

Authors: Kluft C, Burggraaf J

Patients with deep venous thrombosis and thrombophilia risk factors have a specific prolongation of the lag time in a chromogenic thrombin generation assay.

Authors: Haas F.J.L.M, Kluft C, Biesma D.H, Schutgens R.E.G

Updated IMS recommendations on postmenopausal hormone therapy and preventive strategies for midlife health.

Authors: Sturdee D.W, Pines A, Archer D.F, Baber R.J, Barlow D, Birkhäuser M.H, Brincat M, Cardozo L, de Villiers T.J, Gambacciani M, Gompel A.A, Henderson V.W, Kluft C, Lobo R.A, MacLennan A.H, Marsden J, Nappi R.E, Panay N, Pickar J.H, Robinson D, Simon J, Sitruk-Ware R.L, Stevenson J.C

Metabolic profile of a continuous versus a cyclic low-dose combined oral contraceptive after one year of use.

Authors: Rad M, Kluft C, de Kam M.L, Meijer P, Cohen A.F, Grubb G.S, Constantine G.D, Burggraaf J

Desirable global assays.

Author: Kluft C

2003-2010

Biological variation in inflammatory and hemostatic markers.

Authors: Rudez G, Meijer P, Spronk H.M.H, Leebeek F.W.G, ten Cate H, Kluft C, de Maat M.P.M

Cardiovascular risk markers during treatment with estradiol and trimegestone or dydrogesterone.

Authors: Hellgren M, Conrad J, Norris L, Kluft C

ACE inhibition with perindopril and biomarkers of atherosclerosis and thrombosis: results from the PERTINENT study.

Authors: Ceconi C, Fox K.M, Remme W.J, Simoons M.L, Deckers J.W. Bertrand M, Parrinello G, Kluft C, Blann A, Cokkinos D, Ferrari R

Strongly increased levels of fibrinogen elastase degradation products in patients with ischemic stroke.

Authors: de Lau L.M.L, Cheung E.Y.L, Kluft C, Leebeek F.W.G, Meijer P, Laterveer R, Dippel D.W.J, de Maat M.P.M

Inhibitors and activation markers of the haemostatic system during hormone therapy: a comparative study of oral estradiol (2 mg)/ dydrogesterone and estradiol (2 mg)/ trimegestone.

Authors: Norris L.A, Brosnan J, Bonnar J, Conard J, Kluft C, Hellgren M

The impact of metabolic syndrome and CRP on vascular phenotype in type 2 diabetes mellitus.

Authors: Dehnavi R.A, Beishuizen E.D, van de Ree M.A, Le Cessie S, Huisman M.V, Kluft C, Princen H.M.G, Tamsma J.T

Comparison of a transdermal contraceptive patch vs. oral contraceptives on hemostasis variables.

Authors: Kluft C, Meijer P, Laguardia K.D, Fisher A.C

Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects.

Authors: Boomsma D.I, Willemsen G, Sullivan P.F, Heutink P, Meijer P, Sondervan D, Kluft C, Smit A.B, Nolen W.A, Zitman F.G, Smit J.H, Hoogendijk W.J.G, van Dyck R, de Geus E.J.C, Penninx B.W.J.H

Effects of non-oral postmenopausal hormone therapy on markers of cardiovascular risk: a systematic review.

Authors: Hemelaar M, van der Mooren M.J, Rad M, Kluft C, Kenemans P

ACE inhibition with perindopril and endothelial function. Results of a substudy of the EUROPA study: PERTINENT.

Authors: Ceconi C, Fox K.M, Remme W.J, Simoons M.L, Bertrand M, Parrinello G, Kluft C, Cokkinos D, Ferrari R

Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen.

Authors: Sitruk-Ware R.L, Menard J, Rad M, Burggraaf J, de Kam M.L, Tokay B.A, Sivin I, Kluft C

Effects of non-oral postmenopausal hormone therapy on markers of cardiovascular risk: a systematic review.

Authors: Hemelaar M, van der Mooren M.J, Rad M, Kluft C, Kenemans P

Effects of hormone treatment on hemostasis variables.

Author: Kluft C

The impact of metabolic syndrome and CRP on vascular phenotype in type 2 diabetes mellitus.

Authors: Alizadeh Dehnavi R, Beishuizen E.D, van de Ree M.A, Le Cessie S, Huisman M.V, Kluft C, Princen H.M.G, Tamsma J.T

Endothelial binding of recombinant tissue plasminogen activator: quantification in vivo using a recirculatory model.

Authors: Kemme MJ, Schoemaker RC, Burggraaf J, van der Linden M, Noordzij M, Moerland M, Kluft C, Cohen AF

SCIENTIFIC POSTERS

 

IMMUNOLOGY

The inflammasome as future therapeutic target: development of inflammasome challenge tests.

Presented at 5th NCA Nubin symposium, 2014, VUMC, Amsterdam.

Stimulation of TLR7/8 results in direct IL-1β and IL-18 release in human, suggesting a novel pathway for inflammasome activation

Effects of the cholinergic signalling pathway on NLRP3 inflammasome stimulation in human primary cells

Presented at 5th NCA Nubin symposium, 2014, Amsterdam, The Netherlands

METABOLISM

Systems biology approach to identify processes and early markers for fibrosis in a diet-induced NASH mouse model

HEMOSTASIS, COAGULATION & THROMBOSIS

Factor XI level is a determinant of plasma growth

Presented at ISTH 2018, Dublin, Ireland

Role of factor VIII in clot growth and sensitivity to reversible factor Xa inhibitors.

Presented at ISTH 2018, Dublin, Ireland

Fibrinolysis in thrombodynamics

Presented at ISTH 2018, Dublin, Ireland

Mechanism of growth and inhibition of plasma clots growing from a surface with immobilized tissue factor

Presented at ISTH 2017, Berlin, Germany

Comparison of nine different blood collection tubes for contact activation of coagulation

Presented at ISTH 2017, Berlin, Germany

In vitro interactions of sugammadex with various anticoagulants

Presented at ISTH 2016, Montpellier, France

Investigation of Mode of Action of sugammadex effects on coagulation

Presented at ISTH 2016, Montpellier, France

Pharmacodynamic effects of two recombinant FVIIa products in anticoagulated healthy volunteers

Presented at ISTH 2013, Amsterdam, The Netherlands

Pharmacodynamic Effects of Escalating Dosages of a New Recombinant Human Factor VIIa (LR769) in Congenital Hemophilia A or B Patients

Presented at ISTH 2013, Amsterdam, The Netherlands

No clinically relevant interaction between sugammadex and enoxaparin or unfractionated heparin on coagulation

Presented at ISTH 2013, Amsterdam, The Netherlands

Absence of clinically relevant interaction between sugammadex and aspirin on platelet aggregation and coagulation

Presented at ISTH 2013, Amsterdam, The Netherlands

Clot formation and lysis: comparing turbidity and elasticity of plasma fibrin clots

Presented at 59th Annual Meeting of the Society of thrombosis and Hemostasis Research (GTH), 2015, Dusseldorf, Germany

Extra activity in the one stage APTT due to action of factor XIa on factor X causes problems for detection of low levels of factor VIII and IX

Presented at 59th  Annual Meeting of the Society of thrombosis and Hemostasis Research (GTH), 2015, Dusseldorf, Germany

A large effect of rivaroxaban in the PT with specifically Simplastin Excel S may be used for diagnostic purposes.

Presented at 56th Annual Meeting of the Society of thrombosis and Hemostasis Research (GTH), 2012, St.Gallen, Switzerland

Thyroid hormones T3 and T4 and their relationship with fibrinolysis variables

Presented at 20th  International Congress on Fibrinolysis and Proteolysis, 2010, Amsterdam, The Netherlands

The complex of activated protein C and Protein C inhibitor (APC-PCI) in diabetics treated with atorvastatin.

Presented at 20th   International Congress on Fibrinolysis and Proteolysis, 2010, Amsterdam, The Netherlands

Evidence that current reversible thrombin inhibitors show pleiotropic inhibitory effects especially for the intrinsic route of coagulation activation

Published in Pathophysiol Haemost Thromb 37 (Suppl 1) (2009-2010). P531.

Cholesterol ester transfer protein (CETP) levels in patients with suspected deep venous thrombosis

Published in Pathophysiol Haemost Thromb 37 (Suppl 1) (2009-2010). P532

The association of thrombin generation with deep venous thrombosis is age-dependent.

Presented at 20th   International Congress on Fibrinolysis and Proteolysis, 2010, Amsterdam, The Netherlands

OTHER

Netherlands Twin Register (NTR) Biobank Sample Accessibility

Aggression in children: unraveling gene-environment interplay to inform treatment and intervention strategies