2022

Integrative multi-omics analysis of childhood aggressive behavior

Authors: Fiona A. Hagenbeek, Jenny van Dongen, René Pool, Peter J. Roetman, Amy C. Harms,
Jouke Jan Hottenga, Cornelis Kluft, Olivier F. Colins, Catharina E. M. van Beijsterveld,
Vassilios Fanos, Erik A. Ehli, Thomas Hankemeier, Robert R. J. M. Vermeiren, Meike Bartels,
Sébastien Déjean, Dorret I. Boomsma.

2021

A New Pharmacodynamic Test to Evaluate Effects of Oral Contraceptives on Coagulation

de Kruijf P, Naji S, Krijnen C, Jespersen J, and Kluft C
Good Biomarker Sciences, The Netherlands
Department of Public Health, University of Southern Denmark, Denmark

2020

Fibrin deposition, lung failure, fibrosis, effects in many tissues and COVID-19: Proposal that excessive inflammasome activation is the basic disease mechanism.

Author: C. Kluft, kluft@kluft.in

2019

Whole blood assay as a model for in vitro evaluation of inflammasome activation and subsequent caspase-mediated interleukin-1 beta release

Authors: Thi Anh Thu Tran ,Hendrika W. Grievink ,Katarzyna Lipinska,Cornelis Kluft,Jacobus Burggraaf,Matthijs Moerland,Dimitar Tasev,Karen E. Malone

2018

Thrombin Generation in Vitreous and Subretinal Fluid of Patients with Retinal Detachment

Authors: Verena C. Mulder, Jeroen Bastiaans, Cornelis J.M. van Leuven, Jan C. van Meurs, and Cornelis Kluft

Sugammadex hypersensitivity and underlying mechanisms: a randomised study of healthy non-anaesthetised volunteers.

Authors: de Kam PJ et al.

Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3–16 years from multiple raters in six cohorts in the EU-ACTION project

Authors: Bartels M et al.

Characterization of immune cell, endothelial, and renal responses upon experimental human endotoxemia.

Authors: Eveline P. van Poelgeest, Marlous R. Dillingh, Marieke de Kam, Karen E. Malone, Marleen Kemper, Erik S.G. Stroes, Jacobus Burggraaf, Matthijs Moerland

The BCR-ABL1 Inhibitors Imatinib and Ponatinib Decrease Plasma Cholesterol and Atherosclerosis, and Nilotinib and Ponatinib Activate Coagulation in a Translational Mouse Model

Authors: Marianne G. Pouwer, Elsbet J. Pieterman, Lars Verschuren, Martien P. M. Caspers, Cornelis Kluft, Ricardo A. Garcia, Jurjan Aman, J. Wouter Jukema, and Hans M. G. Princen

Adult aggressive behavior in humans and biomarkers: a focus on lipids and methylation

Authors: Fiona A. Hagenbeek, Jenny van Dongen, Cornelis Kluft, Thomas Hankemeier, Lannie Ligthart, Gonneke Willemsen, Eco J.C. de Geus, Jacqueline M. Vink, Meike Bartels, Dorret I. Boomsma

A Dose-Escalating Study With the Fetal Estrogen Estetrol in Healthy Men

Authors:Coelingh Bennink HJT, Zimmerman Y, Verhoeven C, Dutman AE, Mensinga T, Kluft C, Reisman Y, Debruyne FMJ

Genome-wide analysis of DNA methylation in buccal cells: a study of monozygotic twins and mQTLs.

Authors: van Dongen J, Ehli EA, Jansen R, van Beijsterveldt CEM, Willemsen G, Hottenga JJ, Kallsen NA, Peyton SA, Breeze CE5, Kluft C, Heijmans BT, Bartels M, Davies GE, Boomsma DI

2017

Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model.

Authors: van Koppen A, Verschuren L, van den Hoek AM, Verheij J, Morrison MC, Li K, Nagabukuro H, Costessi A, Caspers MPM, van den Broek TJ, Sagartz J, Kluft C, Beysen C, Emson C, van Gool AJ, Goldschmeding R, Stoop R, Bobeldijk-Pastorova I, Turner SM, Hanauer G, Hanemaaijer R.

2SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio.

Lin BD, Carnero-Montoro E, Bell JT, Boomsma DI, de Geus EJ, Jansen R, Kluft C, Mangino M, Penninx B, Spector TD, Willemsen G, Hottenga JJ

Assessing Safety of Thrombolytic Therapy.

Authors: Kluft C, Sidelmann JJ, Gram JB

2016

Clinical Evaluation of Humira® Biosimilar ONS-3010 in Healthy Volunteers: Focus on Pharmacokinetics and Pharmacodynamics

Authors: Dillingh MR, Reijers JA, Malone KE, Burggraaf J, Bahrt K, Yamashita L, Rehrig C, Moerland M

Vitreous and subretinal fluid concentrations of orally administered dabigatran in patients with rheumatogenous retinal detachment.

Authors: Mulder V.C, Kluft C, van Meurs J.C.

Comparison of three isolation techniques for human peripheral blood mononuclear cells: cell recovery and viability, population composition and cell functionality.

Authors: Grievink H.W, Luisman T, Kluft C, Moerland M, Malone K. E

Assessing Safety of Thrombolytic Therapy

Authors: Kluft C, Sidelmann J.J, Gram J.B.

Biological Variation of Hemostasis Variables in Thrombosis and Bleeding: Consequences for Performance Specifications

Authors: Moniek P.M. de Maat, Marianne van Schie, Cornelis Kluft, Frank W.G. Leebeek, and Piet Meijer

Causes of variation in the neutrophil-lymphocyte and platelet-lymphocyte ratios: a twin-family study.

Authors: Lin BD, Hottenga JJ, Abdellaoui A, Dolan CV, de Geus EJ, Kluft C, Boomsma DI, Willemsen G

Discovery of biochemical biomarkers for aggression: A role for metabolomics in psychiatry.

Authors: Hagenbeek FA, Kluft C, Hankemeier T, Bartels M, Draisma HH, Middeldorp CM, Berger R, Noto A, Lussu M, Pool R, Fanos V, Boomsma DI

Characterization of inflammation and immune cell modulation induced by low-dose LPS administration to healthy volunteers

Authors: Dillingh M.R, van Poelgeest E.P, Malone K.E, Kemper E.M, Stroes E.S.G, Moerland M, Burggraaf J

Plasma cotinine levels in cigarette smokers: impact of mental health and other correlates.

Authors: Bot M, Vink J, Milaneschi Y, Smit J.H, Kluft C, Neuteboom J, Penninx B

Applying caspase-1 inhibitors for inflammasome assays in human whole blood.

Authors: Lipinska K, Malone K. E, Moerland M, Kluft C

The contribution of the functional IL6R polymorphism rs2228145, eQTLs and other genome-wide SNPs to the heritability of plasma sIL-6R levels.

Authors: van Dongen J, Jansen R, Smit D, Hottenga J.J, Mbarek H, Willemsen G, Kluft C, Penninx B.W.J, Ferreira M.A, Boomsma D.I. de Geus E.J.C

Effects of sugammadex on activated partial thromboplastin time and prothrombin time in healthy subjects.

Authors: de Kam P.J, Grobara P, Prohn M, Höppener F, Kluft C, Bruggraaf J, Langdon R.B, Peeters P

The association of alcohol intake with γ-glutamyl transferase (GGT) levels: evidence for correlated genetic effects.

Authors: van Beek J.H.D.A, de Moor M.H.M, Geels L.M, Sinke M.R.T, de Geus E.J.C, Lubke G.H, Kluft C, Neuteboom J, Vink J.M, Willemsen G, Boomsma D.I

Consequences for the APTT due to direct action of factor XIa on factor X, resulting in bypassing factors VIII-IX

Authors: Kluft C, van Leuven C.J.M

Exposure to secondhand smoke and depression and anxiety: a report from two studies in the Netherlands.

Authors: Bot M, Vink J.M, Willemsen G, Smit J.H, Neuteboom J, Kluft C, Boomsma D.I, Penninx B.W.J.H

Genetic architecture of the pro-inflammatory state in an extended twin-family design.

Authors: Neijts M, van Dongen J, Kluft C, Boomsma D.I, Willemsen G, de Geus E.J.C

Preincubation in the Prothrombinase-induced Clotting Time test (PiCT) is necessary for in vitro evaluation of fondaparinux and to be avoided for the reversible, direct factor Xa inhibitor, rivaroxaban.

Authors: Kluft C, Meijer P, Kret R, Burggraaf J

Diagnostic possibilities of specific fibrin(ogen) degradation products in relation to venous thromboembolism.

Authors: Haas F.J.L.M, Schutgens R.E.G, Biesma D.H, Laterveer R.H, Kluft C

The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection.

Authors: Willemsen G, Vink J.M, Abdellaoui A, den Braber A, van Beek J.H.D.A, Draisma H.H.M, van Dongen J, van’T Ent D, Geels L.M, van Lien R, Ligthart L, Kattenberg M, Mbarek H, de Moor M.H.M, Neijts M, Pool R, Stroo N, Kluft C, Suchiman H.E.D, Slagboom P.E, de Geus E.J.C, Boomsma D.I

Sex hormone-binding globulin as a marker for the thrombotic risk of hormonal contraceptives: a rebuttal.

Authors: Kluft C, Skouby S.O, Jespersen J, Burggraaf J

Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo.

Authors: Sidelmann J.J, Skouby S.O, Kluft C, Winkler U, Vitzthum F, Schwarz H, Gram J, Jespersen J

Discriminant analysis of the metabolic effects of a new combined contraceptive vaginal ring containing Nestorone/EE vs. a secondgeneration oral contraceptive containing levonorgestrel/EE

Authors: Rad M, Burggraaf J, de Kam ML, Cohen AF, Kluft C.

Introduction to haemostasis from a pharmacodynamic perspective.

Authors: Kluft C, Burggraaf J

Patients with deep venous thrombosis and thrombophilia risk factors have a specific prolongation of the lag time in a chromogenic thrombin generation assay.

Authors: Haas F.J.L.M, Kluft C, Biesma D.H, Schutgens R.E.G

Updated IMS recommendations on postmenopausal hormone therapy and preventive strategies for midlife health.

Authors: Sturdee D.W, Pines A, Archer D.F, Baber R.J, Barlow D, Birkhäuser M.H, Brincat M, Cardozo L, de Villiers T.J, Gambacciani M, Gompel A.A, Henderson V.W, Kluft C, Lobo R.A, MacLennan A.H, Marsden J, Nappi R.E, Panay N, Pickar J.H, Robinson D, Simon J, Sitruk-Ware R.L, Stevenson J.C

Metabolic profile of a continuous versus a cyclic low-dose combined oral contraceptive after one year of use.

Authors: Rad M, Kluft C, de Kam M.L, Meijer P, Cohen A.F, Grubb G.S, Constantine G.D, Burggraaf J

Desirable global assays.

Author: Kluft C

Biological variation in inflammatory and hemostatic markers.

Authors: Rudez G, Meijer P, Spronk H.M.H, Leebeek F.W.G, ten Cate H, Kluft C, de Maat M.P.M

Cardiovascular risk markers during treatment with estradiol and trimegestone or dydrogesterone.

Authors: Hellgren M, Conrad J, Norris L, Kluft C

ACE inhibition with perindopril and biomarkers of atherosclerosis and thrombosis: results from the PERTINENT study.

Authors: Ceconi C, Fox K.M, Remme W.J, Simoons M.L, Deckers J.W. Bertrand M, Parrinello G, Kluft C, Blann A, Cokkinos D, Ferrari R

Strongly increased levels of fibrinogen elastase degradation products in patients with ischemic stroke.

Authors: de Lau L.M.L, Cheung E.Y.L, Kluft C, Leebeek F.W.G, Meijer P, Laterveer R, Dippel D.W.J, de Maat M.P.M

Inhibitors and activation markers of the haemostatic system during hormone therapy: a comparative study of oral estradiol (2 mg)/ dydrogesterone and estradiol (2 mg)/ trimegestone.

Authors: Norris L.A, Brosnan J, Bonnar J, Conard J, Kluft C, Hellgren M

The impact of metabolic syndrome and CRP on vascular phenotype in type 2 diabetes mellitus.

Authors: Dehnavi R.A, Beishuizen E.D, van de Ree M.A, Le Cessie S, Huisman M.V, Kluft C, Princen H.M.G, Tamsma J.T

Comparison of a transdermal contraceptive patch vs. oral contraceptives on hemostasis variables.

Authors: Kluft C, Meijer P, Laguardia K.D, Fisher A.C

Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects.

Authors: Boomsma D.I, Willemsen G, Sullivan P.F, Heutink P, Meijer P, Sondervan D, Kluft C, Smit A.B, Nolen W.A, Zitman F.G, Smit J.H, Hoogendijk W.J.G, van Dyck R, de Geus E.J.C, Penninx B.W.J.H

Effects of non-oral postmenopausal hormone therapy on markers of cardiovascular risk: a systematic review.

Authors: Hemelaar M, van der Mooren M.J, Rad M, Kluft C, Kenemans P

ACE inhibition with perindopril and endothelial function. Results of a substudy of the EUROPA study: PERTINENT.

Authors: Ceconi C, Fox K.M, Remme W.J, Simoons M.L, Bertrand M, Parrinello G, Kluft C, Cokkinos D, Ferrari R

Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen.

Authors: Sitruk-Ware R.L, Menard J, Rad M, Burggraaf J, de Kam M.L, Tokay B.A, Sivin I, Kluft C

Effects of non-oral postmenopausal hormone therapy on markers of cardiovascular risk: a systematic review.

Authors: Hemelaar M, van der Mooren M.J, Rad M, Kluft C, Kenemans P

Effects of hormone treatment on hemostasis variables.

Author: Kluft C

The impact of metabolic syndrome and CRP on vascular phenotype in type 2 diabetes mellitus.

Authors: Alizadeh Dehnavi R, Beishuizen E.D, van de Ree M.A, Le Cessie S, Huisman M.V, Kluft C, Princen H.M.G, Tamsma J.T