Primary human cell systems offer the most relevant cell types for the evaluation of early innate immune responses and inflammation, as well as more generalized processes associated with cell stress. GBS can help you to design assays with primary human cell based systems such as Xvi-Blood to fully characterize the immune modulating or immunotoxic potential your products.
Upon incubation with Xvi-Blood assay, a tested compound exert a specific biological response which can be characterized by measuring of immune biomarkers (IL-1β, IL-6, TNF-α, etc) or by flow cytometry detection of specific cell population that responds to the tested compound.
Our cell-based models for investigation of immunomodulation and inflammation are suitable to investigate the biological effect of your product in context to specific TLR or inflammasome activation.
CELL LINE MODELS
We also utilize the human monocyte cell line, THP-1, which can be differentiated in vitro to achieve various macrophage phenotypes. Most of our models are also applicable to this immortalized cell line and can serve as a first line of bioassay development for many immune modulators.