The role of epigenetic mechanisms in allergic disease is under active investigation, because these mechanisms are known to be at the interface among gene regulation, environmental stimuli and developmental processes, all of which are essential for the pathogenesis of asthma and allergy diseases.
In collaboration with local partners, GBS Leiden are able to offer genome-wide DNA methylation profiling on state of the art platform, the MethylationEPIC BeadChip (Infinium) microarray. This platform covers approximately 850,000 CpG methylation sites throughout the genome, providing quantitative methylation measurement at the single-CpG–site level, which offers powerful resolution for understanding epigenetic changes.
Identification of genes involved in the pathogenesis of allergy and/or asthma and as predictor of disease, phenotypic determination, distinguish between allergic and non-allergic as well as allergic and sensitized individuals.
Depending on the scope of the study, our team here at GBS Leiden can help every step of the way with the study design, web-lab expertise, samples requirement as well as data analysis and interpretation.